abstract：BACKGROUND:Acetaminophen (APAP) overdose induces massive hepatocyte necrosis. Liver regeneration is a vital process for survival after a toxic insult. Since hepatocytes are mostly in a quiescent state (G0), the regeneration process requires the priming of hepatocytes by cytokines such as TNF-α and IL-6. Ringer's lactat...

journal_title：BMC gastroenterology

authors： Yang R,Zhang S,Kajander H,Zhu S,Koskinen ML,Tenhunen J

更新日期：2011-11-15 00:00:00

abstract：BACKGROUND:Imatinib mesylate has been the standard therapeutic treatment for chronic myeloid leukemia, advanced and metastatic gastrointestinal stromal tumor (GIST). It is well tolerated with mild adverse effects. Gynecomastia development during the course of treatment has been rarely reported. METHODS:Ninety-eight pa...

journal_title：BMC gastroenterology

authors： Liu H,Liao G,Yan Z

更新日期：2011-11-02 00:00:00

abstract：BACKGROUND:Translocation of gut-derived bacterial products such as endotoxin is a major problem in liver cirrhosis. METHODS:To assess the hepatic clearance of bacterial products in individuals with cirrhosis, we tested concentrations of Gram-negative bacterial lipopolysaccharide (LPS), LPS-binding protein (LBP), and t...

journal_title：BMC gastroenterology

authors： Benten D,Schulze zur Wiesch J,Sydow K,Koops A,Buggisch P,Böger RH,Gaydos CA,Won H,Franco V,Lohse AW,Ray SC,Balagopal A

更新日期：2011-10-06 00:00:00

abstract：BACKGROUND:Primary sclerosing cholangitis (PSC) is a rare chronic cholestatic liver disease often associated with inflammatory bowel diseases (IBD). Current epidemiological data are limited to studies of predominantly Caucasian populations. Our aim was to define the epidemiology of PSC in a large, ethnically diverse US...

journal_title：BMC gastroenterology

authors： Toy E,Balasubramanian S,Selmi C,Li CS,Bowlus CL

更新日期：2011-07-18 00:00:00

abstract：BACKGROUND:Allergic proctocolitis (APC) in exclusively breast-fed infants is caused by food proteins, deriving from maternal diet, transferred through lactation. In most cases a maternal cow milk-free diet leads to a prompt resolution of rectal bleeding, while in some patients a multiple food allergy can occur. The aim...

journal_title：BMC gastroenterology

authors： Lucarelli S,Di Nardo G,Lastrucci G,D'Alfonso Y,Marcheggiano A,Federici T,Frediani S,Frediani T,Cucchiara S

更新日期：2011-07-16 00:00:00

abstract：BACKGROUND:Advances in intensive care support such as therapeutic hypothermia or new liver assist devices have been the mainstay of treatment attempting to bridge the gap from acute liver failure to liver transplantation, but the efficacy of the available devices in reducing mortality has been questioned. To address th...

journal_title：BMC gastroenterology

authors： Thiel K,Schenk M,Etspüler A,Schenk T,Morgalla MH,Königsrainer A,Thiel C

更新日期：2011-07-14 00:00:00

abstract：BACKGROUND:Erdheim-Chester disease (ECD) is a rare multisystem non-Langerhans cell histiocytosis that is characterized histologically by xanthogranulomatous infiltrates and radiologically by symmetrical sclerosis of long bones. The xanthomatous process is characterized by prominent foamy histiocytes staining positive f...

journal_title：BMC gastroenterology

authors： Pan A,Doyle T,Schlup M,Lubcke R,Schultz M

更新日期：2011-06-22 00:00:00

abstract：BACKGROUND:Although the outcomes of caustic ingestion differ between children and adults, it is unclear whether such outcomes differ among adults as a function of their age. This retrospective study was performed to ascertain whether the clinical outcomes of caustic ingestion differ significantly between elderly and no...

journal_title：BMC gastroenterology

authors： Chang JM,Liu NJ,Pai BC,Liu YH,Tsai MH,Lee CS,Chu YY,Lin CC,Chiu CT,Cheng HT

更新日期：2011-06-14 00:00:00

abstract：BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive carcinomas of the gastrointestinal tract. We assessed the relevance of Slug in measuring the invasive potential of ESCC cells in vitro and in vivo in immunodeficient mice. METHODS:We utilized RNA interference to knockdown Slug gene expr...

journal_title：BMC gastroenterology

authors： Tang P,Yu Z,Zhang K,Wang Y,Ma Z,Zhang S,Chen D,Zhou Y

更新日期：2011-05-20 00:00:00

abstract：BACKGROUND:Microscopic colitis presents with similar symptoms to classic inflammatory bowel diseases. Osteoporosis is a common complication of Crohn's disease but there are no data concerning bone metabolism in microscopic colitis. AIMS:The aim of the present study was to evaluate bone density and metabolism in patien...

journal_title：BMC gastroenterology

authors： Lorinczy K,Lakatos G,Müllner K,Hritz I,Lakatos PL,Tulassay Z,Miheller P

更新日期：2011-05-19 00:00:00

abstract：BACKGROUND:We prepared an oral W/O microemulsion for the removal of colonic ammonia (ME-RCA). The effect of this microemulsion was influenced by the digestion process in the gastrointestinal tract. In this paper, we aim to show that stability was improved by using a microemulsion-based gel for the removal of colonic am...

journal_title：BMC gastroenterology

authors： Wang AH,Duan ZJ,Tian G,Lu D,Zhang WJ,He GH,Fang GH

更新日期：2011-05-10 00:00:00

abstract：BACKGROUND:Transient elastography (TE) is an innovative, noninvasive technique to assess liver fibrosis by measuring liver stiffness in patients with chronic liver diseases. The purpose of this study has been to explore the accuracy of TE and clinical parameters in predicting the presence of esophageal/gastric varices ...

journal_title：BMC gastroenterology

authors： Chongsrisawat V,Vejapipat P,Siripon N,Poovorawan Y

更新日期：2011-04-18 00:00:00

abstract：BACKGROUND:FibroTest (FT) is a validated biomarker of fibrosis. To assess the applicability rate and to reduce the risk of false positives/negatives (RFPN), security algorithms were developed. The aims were to estimate the prevalence of RFPN and of proven failures, and to identify factors associated with their occurren...

journal_title：BMC gastroenterology

authors： Poynard T,Munteanu M,Deckmyn O,Ngo Y,Drane F,Messous D,Castille JM,Housset C,Ratziu V,Imbert-Bismut F

更新日期：2011-04-14 00:00:00

abstract：BACKGROUND:Nodular lymphoid hyperplasia of gastrointestinal tract is a rare disorder, often associated with immunodeficiency syndromes. There are no published reports of its association with Helicobacter pylori infection. METHODS:From March 2005 till February 2010, we prospectively followed all patients with diffuse d...

journal_title：BMC gastroenterology

authors： Khuroo MS,Khuroo NS,Khuroo MS

更新日期：2011-04-11 00:00:00

abstract：BACKGROUND:Real-time tissue sonoelastography (EG) is a new non-invasive technique that visualizes differences in tissue strain. We evaluated the usefulness of EG in patients with ulcerative colitis (UC) by investigating the association between EG and colonoscopic findings and disease activity. METHODS:Thirty-seven UC ...

journal_title：BMC gastroenterology

authors： Ishikawa D,Ando T,Watanabe O,Ishiguro K,Maeda O,Miyake N,Nakamura M,Miyahara R,Ohmiya N,Hirooka Y,El-Omar EM,Goto H

更新日期：2011-03-31 00:00:00

abstract：BACKGROUND:Biliary atresia (BA) is a progressive inflammatory disorder of the extrahepatic bile ducts leading to the obliteration of bile flow. The purpose of this study was to determine serum adiponectin in BA patients and to investigate the relationship of adiponectin with clinical parameters and liver stiffness scor...

journal_title：BMC gastroenterology

authors： Honsawek S,Chayanupatkul M,Chongsrisawat V,Theamboonlers A,Praianantathavorn K,Udomsinprasert W,Vejchapipat P,Poovorawan Y

更新日期：2011-02-28 00:00:00

abstract：BACKGROUND:The transitional-CpG sites between weakly methylated genes and densely methylated retroelements are overmethylated in the gastric mucosa infected with Helicobacter pylori (H. pylori) and they are undermethylated in the gastric cancers depending on the level of loss of heterozygosity (LOH) events. This study ...

journal_title：BMC gastroenterology

authors： Hong SJ,Oh JH,Jeon EJ,Min KO,Kang MI,Choi SW,Rhyu MG

更新日期：2010-11-20 00:00:00

abstract：BACKGROUND:From the morphological appearance, it was impossible to distinguish terminal portal venules from small lymphatic vessels in the portal tract even using histochemical microscopic techniques. Recently, D2-40 was found to be expressed at a high level in lymphatic endothelial cells (LECs). This study was underta...

journal_title：BMC gastroenterology

authors： Yokomori H,Oda M,Kaneko F,Kawachi S,Tanabe M,Yoshimura K,Kitagawa Y,Hibi T

更新日期：2010-11-08 00:00:00

abstract：BACKGROUND:Although laparoscopic surgery has been available for a long time and laparoscopic cholecystectomy has been performed universally, it is still not clear whether open appendectomy (OA) or laparoscopic appendectomy (LA) is the most appropriate surgical approach to acute appendicitis. The purpose of this work is...

journal_title：BMC gastroenterology

authors： Li X,Zhang J,Sang L,Zhang W,Chu Z,Li X,Liu Y

更新日期：2010-11-03 00:00:00

abstract：BACKGROUND:The oral multi-kinase inhibitor sunitinib malate improves the survival of patients with gastrointestinal stromal tumors (GIST) after the disease progresses or intolerance to imatinib mesylate develops. Urinary fistulae arising during treatment with sunitinib for GIST have not been described. CASE PRESENTATI...

journal_title：BMC gastroenterology

authors： Watanabe K,Otsu S,Morinaga R,Kawano S,Hirashima Y,Sakashita H,Shirao K

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:The association between proinflammatory cytokine gene polymorphisms and gastric diseases related to Helicobacter pylori varies by population and geographic area.Our objective was to determine if the IL-1B -511 T>C and -31 C>T polymorphisms and H. pylori vacA genotypes are associated with risk of chronic gast...

journal_title：BMC gastroenterology

authors： Martínez-Carrillo DN,Garza-González E,Betancourt-Linares R,Mónico-Manzano T,Antúnez-Rivera C,Román-Román A,Flores-Alfaro E,Illades-Aguiar B,Fernández-Tilapa G

更新日期：2010-10-27 00:00:00

abstract：BACKGROUND:Idiopathic portal hypertension (IPH) is a disorder of unknown etiology and is characterized clinically by portal hypertension, splenomegaly, and hypersplenism accompanied by pancytopenia. This study evaluates the pathogenic concept of the disease by a systematic review of the literature and illustrates novel...

journal_title：BMC gastroenterology

authors： Däbritz J,Worch J,Materna U,Koch B,Koehler G,Duck C,Frühwald MC,Foell D

更新日期：2010-10-20 00:00:00

abstract：BACKGROUND:Esophagogastroduodenoscopy is an often-used and safe diagnostic method in gastroenterology. Transnasal esophagogastroduodenoscopy is now an established addition to the endoscopic instrumentarium. Although the two examination methods can be used alongside each other, there is a lack of studies on the comparab...

journal_title：BMC gastroenterology

authors： Aymaz S,Krakamp B,Kirschberg O,Lefering R

更新日期：2010-10-13 00:00:00

abstract：BACKGROUND:The rate of H. pylori infection in Vietnam is reportedly high, but the spectrum of H. pylori-associated gastroduodenal diseases has not been systematically investigated. Moreover, despite the similarities of ethnicity and diet, the age-standardized incidence rate of gastric cancer in the northern city of Han...

journal_title：BMC gastroenterology

authors： Nguyen TL,Uchida T,Tsukamoto Y,Trinh DT,Ta L,Mai BH,Le SH,Thai KD,Ho DD,Hoang HH,Matsuhisa T,Okimoto T,Kodama M,Murakami K,Fujioka T,Yamaoka Y,Moriyama M

更新日期：2010-09-30 00:00:00

abstract：BACKGROUND:The value of abdominal echography in primary care is great because it is innocuous, inexpensive, easy to perform and provides a great deal of information making this the first examination to be requested in cases of probable abdominal disease. However, too many abdominal echographies are probably requested o...

journal_title：BMC gastroenterology

authors： Auladell MA,Caballeria L,Pera G,Rodríguez L,Casas JD,Aznar J,Miranda D,Sánchez C,Negrete A,Castellví JM,Bernad J,Canut S,Aubà J,Aizpurua MM,Torán P

更新日期：2010-09-06 00:00:00

abstract：BACKGROUND:Endoscopic treatments, such as endoscopic submucosal dissection (ESD) and laparoscopic gastrectomy, are increasingly used to treat a subset of patients with early gastric cancer (EGC). To achieve successful outcomes, it is very important to accurately determine the lateral extent of the tumor. Therefore, we ...

journal_title：BMC gastroenterology

authors： Lee BE,Kim GH,Park DY,Kim DH,Jeon TY,Park SB,You HS,Ryu DY,Kim DU,Song GA

更新日期：2010-08-23 00:00:00

abstract：BACKGROUND:Haemorrhoids are a common problem in daily practice. However, symptoms may also be caused by other abnormalities in the rectum or colon. Data on the presence of these abnormalities in patients with haemorrhoids is sparse. To examine the prevalence of abnormalities of the colon or rectum in patients with and ...

journal_title：BMC gastroenterology

authors： Koning MV,Loffeld RJ

更新日期：2010-07-07 00:00:00

abstract：BACKGROUND:Pancreatic cancer has significant morbidity and mortality worldwide. Good prognosis relies on an early diagnosis. The purpose of this study was to develop techniques for identifying cancer biomarkers in the serum of patients with pancreatic cancer. METHODS:Serum samples from five individuals with pancreatic...

journal_title：BMC gastroenterology

authors： Rong Y,Jin D,Hou C,Hu J,Wu W,Ni X,Wang D,Lou W

更新日期：2010-06-29 00:00:00

abstract：BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) includes a wide spectrum of liver diseases, ranging from pure steatosis to nonalcoholic steatohepatitis (NASH), and eventually to liver cirrhosis with its complications. Identifying advanced fibrosis in patients is crucial to evaluating prognosis and possible therapeu...

journal_title：BMC gastroenterology

authors： Raszeja-Wyszomirska J,Szymanik B,Ławniczak M,Kajor M,Chwist A,Milkiewicz P,Hartleb M

更新日期：2010-06-28 00:00:00

abstract：BACKGROUND:There is insufficient evidence on the effectiveness of acupuncture for irritable bowel syndrome (IBS) for conclusions to be drawn. Given the current interest in acupuncture by patients, it is in the public interest to establish more rigorous evidence. Building on the positive findings from a pilot study, in ...

journal_title：BMC gastroenterology

authors： MacPherson H,Bland M,Bloor K,Cox H,Geddes D,Kang'ombe A,Reynolds J,Stamuli E,Stuardi T,Tilbrook H,Torgerson D,Whorwell P

更新日期：2010-06-17 00:00:00

abstract：BACKGROUND:Gastric cancer can progress from a chronic inflammation of the gastric mucosa resulting from Helicobacter pylori infection that activates the inflammatory response of the host. Therefore, polymorphisms in genes involved in the inflammatory response, such as inducible nitric oxide synthase (NOS2), have been i...

journal_title：BMC gastroenterology

authors： Jorge YC,Duarte MC,Silva AE

更新日期：2010-06-17 00:00:00

abstract：BACKGROUND:Capillary patterns (CP) observed by magnifying Narrow Band Imaging (NBI) are useful for differentiating non-adenomatous from adenomatous colorectal polyps. However, there are few studies concerning the effectiveness of magnifying NBI for determining the depth of invasion in early colorectal neoplasms. We aim...

journal_title：BMC gastroenterology

authors： Ikematsu H,Matsuda T,Emura F,Saito Y,Uraoka T,Fu KI,Kaneko K,Ochiai A,Fujimori T,Sano Y

更新日期：2010-03-27 00:00:00

abstract：BACKGROUND:Inflammation and immune activation have repeatedly been suggested as pathogentic factors in irritable bowel syndrome (IBS). The driving force for immune activation in IBS remains unknown. The aim of our study was to find out if the obligate intracellular pathogen Chlamydia could be involved in the pathogenes...

journal_title：BMC gastroenterology

authors： Dlugosz A,Törnblom H,Mohammadian G,Morgan G,Veress B,Edvinsson B,Sandström G,Lindberg G

更新日期：2010-02-16 00:00:00

abstract：BACKGROUND:There are many pathological conditions with hepatic iron overload. Classical definite diagnostic methods of these disorders are invasive and based on a direct tissue biopsy material. For the last years the role of MR imaging in liver diagnostics has been increasing. MRI shows changes of liver intensity in pa...

journal_title：BMC gastroenterology

authors： Szurowska E,Sikorska K,Izycka-Swieszewska E,Nowicki T,Romanowski T,Bielawski KP,Studniarek M

更新日期：2010-01-27 00:00:00

abstract：BACKGROUND:Infliximab is usually administered by two monthly intravenous (iv) infusions, therefore requiring visits to hospital. Adalimumab is administered by self subcutaneous (sc) injections every other week. Both of these anti-TNF drugs appear to be equally efficacious in the treatment of Crohn's Disease and therefo...

journal_title：BMC gastroenterology

authors： Allen PB,Lindsay H,Tham TC

更新日期：2010-01-10 00:00:00

abstract：BACKGROUND:We aimed to provide empirical evidence of how spectrum effects can affect the sensitivity of histological assessment of Helicobacter pylori infection, which may contribute to explain the heterogeneity in prevalence estimates across populations with expectedly similar prevalence. METHODS:Cross-sectional eval...

journal_title：BMC gastroenterology

authors： Lunet N,Peleteiro B,Carrilho C,Figueiredo C,Azevedo A

更新日期：2009-12-24 00:00:00

abstract：BACKGROUND:Benign biliary strictures may be a consequence of surgical procedures, chronic pancreatitis or iatrogenic injuries to the ampulla. Stents are increasingly being used for this indication, however it is not completely clear which stent type should be preferred. METHODS:A systematic review on stent placement f...

journal_title：BMC gastroenterology

authors： van Boeckel PG,Vleggaar FP,Siersema PD

更新日期：2009-12-17 00:00:00

abstract：BACKGROUND:The clinical course of chronic pancreatitis is still unpredictable, which relates to the lack of the availability of a clinical classification. Therefore, patient populations cannot be compared, the course and the outcome of the disease remain undetermined in the individual patient, and treatment is not stan...

journal_title：BMC gastroenterology

authors： Büchler MW,Martignoni ME,Friess H,Malfertheiner P

更新日期：2009-12-14 00:00:00

abstract：BACKGROUND:Liver fibrosis is the result of continuous liver injury stemming from different etiological factors. Bile duct injury induces an altered expression of TGF-beta, which has an important role in liver fibrosis because this cytokine induces the expression of target genes such as collagens, PAI-1, TIMPs, and othe...

journal_title：BMC gastroenterology

authors： del Pilar Alatorre-Carranza M,Miranda-Díaz A,Yañez-Sánchez I,Pizano-Martínez O,Hermosillo-Sandoval JM,Vázquez-Del Mercado M,Hernández-Hoyos S,Martínez-Abundis R,Fafutis-Morris M,Segura-Ortega J,Delgado-Rizo V

更新日期：2009-10-31 00:00:00

abstract：BACKGROUND:Intestinal metaplasia (IM) is an important precursor lesion in the development of gastric cancer (GC). The aim of this study was to investigate genetic factors previously linked to GC risk for their possible association with IM. A total of 18 polymorphisms in 14 candidate genes were evaluated in a Singapore-...

journal_title：BMC gastroenterology

authors： Zhu F,Loh M,Hill J,Lee S,Koh KX,Lai KW,Salto-Tellez M,Iacopetta B,Yeoh KG,Soong R,Singapore Gastric Cancer Consortium.

更新日期：2009-10-13 00:00:00